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MODY Is Prevalent in Later-Onset Diabetes and Has Potential for Targeted Therapy but Is Challenging to Identify.

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Affiliations

  • 1. Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, U.K.
      Authors
    • Sharp LN 1
    • Colclough K 1
    • Hall TS 1
    • Cannon SJ 1
    • Laver TW 1
    • Weedon MN 1
    • Hattersley AT 1
    • Patel KA 1
    (8 authors)
  • 2. Department of Genomic Health, Geisinger, Danville, PA.
      Authors
    • Mirshahi UL 2
    • Haley JS 2
    • Carey DJ 2
    (3 authors)

ORCIDs linked to this article

Diabetes, 01 Jan 2026, 75(2):361-368
https://doi.org/10.2337/db25-0545 PMID: 41288518 PMCID: PMC7618620

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Abstract 

Article highlights

Maturity-onset diabetes of the young (MODY) can present later in life, and diagnosis can enable precision treatment. However, individuals with later-onset diabetes are rarely tested. How common is MODY in people diagnosed with diabetes after age 40 years? Can they be identified clinically? MODY affects 1 in 191-633 individuals with diabetes onset after 40 years, but clinical features alone cannot reliably identify them. MODY is relatively common in later-onset diabetes but difficult to detect clinically, limiting routine genetic testing in this group.

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Read article at publisher's site: https://doi.org/10.2337/db25-0545

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    Funding 

    Funders who supported this work.

    Academy of Medical Sciences (1)

    • Grant ID: SBF009\1135

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    Diabetes UK (2)

    • Grant ID: 19/0005994

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    • Grant ID: 21/0006335

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    Medical Research Council (1)

    • Grant ID: MR/T00200X/1

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    NIHR Exeter Clinical Research Facility

      Regeneron Genetics Center

        Wellcome Trust (2)

        • Grant ID: 219606

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        • Grant ID: 219606/Z/19/Z

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