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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

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Collaborators (67)

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Affiliations

  • 1. Life and Medical Sciences (LIMES) Institute, University of Bonn, Germany.
      Authors
    • Schulte-Schrepping J 1
    • Reusch N 1
    • Baßler K 1
    • Bonaguro L 1
    • Kapellos TS 1
    • Pecht T 1
    • Horne A 1
    • Herbert M 1
    (8 authors)
  • 2. Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany.
      Authors
    • Paclik D 2
    • Schneider M 2
    • Sawitzki B 2
    (3 authors)
  • 3. Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany; BIH Center for Regenerative Therapies, Charité, Universitätsmedizin Berlin, and Berlin Institute of Health (BIH) Berlin, Germany.
      Authors
    • Schlickeiser S 3
    (1 author)
  • 4. Centre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.
      Authors
    • Zhang B 4
    • Grasshoff M 4
    • Beckstette M 4
    (3 authors)
  • 5. Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
      Authors
    • Krämer B 5
    • Raabe J 5
    • Kaiser KM 5
    • Vinh MT 5
    • Rieke G 5
    (5 authors)
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Cell, 05 Aug 2020, 182(6):1419-1440.e23
https://doi.org/10.1016/j.cell.2020.08.001 PMID: 32810438 PMCID: PMC7405822

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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Abstract 

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

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Read article at publisher's site: https://doi.org/10.1016/j.cell.2020.08.001

Read article for free, from open access legal sources, via Unpaywall: http://hdl.handle.net/10033/622503Unpaywall

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    Funding 

    Funders who supported this work.

    Bundesministerium für Bildung und Forschung

      Deutsche Forschungsgemeinschaft

        Deutsches Zentrum für Infektionsforschung

          European Commission

            Helmholtz Association

              Radboud Universitair Medisch Centrum

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